9 events the sources record for this year, grouped by region.
What happened
China (2)
Prince Anhua Zhu Zhenfan rebelled at Ningxia and killed the Governor An Weixue and Commander Jiang Han (soon captured by Qiu Yue). (History of Ming (Mingshi), Annals 明史 卷16 正德五年)
Isma'il defeated the Uzbeks near Merv, and Shaibani fell in battle. (Baburnama (Memoirs of Babur) Beveridge 영역 1권, 916 AH 부분, 원문 파일 806행 부근)
The Uzbek sultans Mahdi and Hamza of Hisar came out to Vakhsh to face him, but withdrew without fighting. (Baburnama (Memoirs of Babur) Beveridge 영역 1권, 916 AH 부분, 원문 파일 26272행 부근)
Southeast Asia (3)
At the third watch of the night of the 25th day of the 4th month, Wan Ke-sa rebelled and forced the emperor into the Zhonghua palace. (Đại Việt sử ký toàn thư 本紀卷之十五 「'''庚午，洪順二年（明正德五年」)
Mahmud believed the slander of Raja Mudeliar and executed the prime minister Sri Maha Raja, his sons, brothers and son-in-law. (Malay Annals (Sejarah Melayu) Leyden 1821 p.340)
Overcome with remorse, Mahmud enthroned his son Ahmad and withdrew to the mountains above Malacca. (Malay Annals (Sejarah Melayu) Leyden 1821 p.349)
Sub-Saharan Africa (1)
Askia sends Alipolen and Belmaa Muhammad Karai as envoys to Bagena Paran (Tarikh al-Sudan (Chronicle of the Sudan) Houdas 1900 불역 장 XIII (houdas1900_fr_djvu.txt 줄 6214))
Eastern Europe & Russia (1)
The khan's son Burnash Girey approached Ryazan castle and took part of the outer wall, but could not get the town. (Karamzin, History of the Russian State 제7권 II장)